• Cikkarchívum
    • Általános fogászat
    • COVID-19
    • Endodontia
    • Esztétika
    • Fogtechnika
    • Orthodontia
    • Lézer technológia
    • Implantológia
    • Parodontológia
    • Praxismenedzsment
    • Protetika
    • Szájhigiénia
    • DNEWS
  • Apróhirdetés
    • Apróhirdetések
    • Hirdetés feladása
  • Webshop
  • Rendezvények
    • Upgrade Congress 2023
    • Dental World 2023
  • Médiaajánló
    • Média ajánló
    • Dental Press Media offers
  • Kapcsolat
Nincs találat
Összes találat

Nincsenek termékek a kosárban.

Dental.hu
  • Szakmai Hírek
  • Endodontia
  • Esztétika
  • Implantológia
  • Orthodontia
  • Szájhigiénia
  • Fogtechnika
  • E-JOURNAL
  • Videótár
  • Szakmai Hírek
  • Endodontia
  • Esztétika
  • Implantológia
  • Orthodontia
  • Szájhigiénia
  • Fogtechnika
  • E-JOURNAL
  • Videótár
Nincs találat
Összes találat
Dental.hu
Nincs találat
Összes találat
Főoldal DNEWS

A new era of advanced dental restorative materials has begun
By Monique Mehler, Dental Tribune International

2022-05-20
DNEWS
Olvasási idő: 4 perc
A new era of advanced dental restorative materials has begun By Monique Mehler, Dental Tribune International
Megosztom FacebookonMegosztom LinkedinenElküldöm emailben

“Many have tried; few have succeeded” is a saying that certainly rings true in the case of Prof. Ervin Weiss from Israel. Several years after he graduated from dental school in his home country, he relocated to the US, where he worked at the National Institutes of Health for three years and trained to become a microbiologist. Back “This is the first restorative material in dentistry that treats a disease while restoring function, aesthetics and phonetics,”— Prof. Weiss said when speaking about Nobio’s goals for Infinix.

 

in Israel, he became a lecturer in restorative dentistry, finding his calling in teaching and mentoring the next generation of dental professionals. However, this is not Prof. Weiss’s only passion. The combination of his sci-entific background and sheer endless curiosity led him to reflect on the lack of efficiency of traditional restorative dental composites and their high failure rate. He sought to find an antimicrobial material with permanently integrated activity, but none had been developed, and he was continually told that such a product was an im-possibility. Driven by this unsatisfactory answer and his idea, what started as a mission to find a solution to this problem became his legacy: the world’s first antimicrobial composite—and it might change dentistry forever.

That dental composites have many shortcomings is a well-known and scientifically backed fact. Indeed, it was shown by Mjör in 20051 and Kopperud et al. in 20122 that up to two-thirds of all restorative dental treatments involve the replacement of failed restorations because they are more prone to recurrent decay (due to the microleakage that results from shrinkage on polymerisation), debonding, technique sensitivity and the degradation of resin by oral bacteria. As reported in a market analysis published by Grand View Research, in the US alone, 200 million cavities are treated every year, and that means about 133 million dental fillings that will fail.3

In an interview with Dental Tribune International (DTI), Prof. Weiss stressed that preventive oral healthcare is the only answer to addressing oral disease, and restorative care cannot do so; however, restorative treatment is a necessity at times. This is where Prof. Weiss and his com-pany Nobio come in, offering a technology that “trans-forms materials, products and surfaces to antimicrobial, with its revolutionary particles, providing strong, safe and durable bio-protection, for life”.

How it works 

In essence, Nobio’s quaternary ammonium silica (QASi) particles exert concentrated electrostatic stress on bacteria that come in direct contact with the restorative “Now, instead of acting as surgeons and just cutting away the disease and restoring what is left as  technicians, dentists can treat the disease itself, much like any other medical treatment.”

material, causing their death, Prof. Weiss explained. “When bacteria touch the nanoparticles incorporated into the surface of the composite, the bacteria explode and die. This way, the acidity in the oral cavity is reduced and teeth cannot demineralise,” he continued. 

By killing these bacteria, which would usually promote demineralisation and subsequent carious lesions, Infinix composites reduce this mineral loss, preserving the restoration over time. Nobio’s Infinix family of compos-ite products are the first to be cleared by the U.S. Food and Drug Administration (FDA) for reducing tooth decay. In clinical trials, the antibacterial composites significantly reduced tooth demineralisation.5

Laboratory studies have shown that the QASi particles are potent antibacterial agents, do not leach out, inhibit the breakdown of the composite and maintain their antibacterial activity. Infinix composites were the only composites to maintain neutral pH in the presence of oral bacteria and sugar in a comparison with three conventional, widely used composites.6

The range consists of four products. For an antibacterial cavity cleansing effect, Infinix Universal Bond is a general-purpose, light-polymerised, self-etching bonding system (prime and bond). It provides strong adhesion between enamel, dentine and all types of restorative materials. Infinix Flowable Composite is a single-step, light-polymerised, low-viscosity flowable composite. It can be used for Class III and V restorations, ideally as a base and liner in direct restorations, as well as a pit and fissure sealant. Infinix Bulk-Fill Flow Composite is a low-viscosity composite with a high depth of polymerisation. It is ideal for posterior restorations, which are more prone to recurrent caries. Infinix Universal Composite is a light-polymerised, high-viscosity universal restorative composite which performs across a variety of conditions. 

The control composite (top) shows bacterial growth after 1 hour and a thick biofilm after 24 hours. The antibacterial filler (bottom) shows broken down bacteria after 1 hour and no live bacteria on the surface after 24 hours, respectively. (All images: © Nobio)
Clinical study confirms efficiency

From 2019 to 2020, the University of California, San Francisco (UCSF) in the US collaborated with Nobio in a clinical trial that tested the antibacterial composite in 25 patients who wore mandibular partial dentures with acrylic flanges on both sides of the mouth.7 The research-ers recessed a human enamel slab and a composite separated by a tiny gap into the flanges, employing Infinix in one flange and a standard composite as a control in the other. The participants were not aware of which side of the denture contained which composite. This gap model simulated a faulty tooth–restoration interface and then exposed it to cariogenic challenge. 

After a four-week wearing period, samples were assessed in the laboratory using cross-sectional micro-hardness testing of the enamel. The UCSF researchers found that the average mineral loss for the Nobio side was significantly lower (nearly 70%) than for the control side in every patient.

A detailed illustration of Nobio’s quaternary ammonium silica technology demonstrates how the material works in the oral cavity.
Welcome to the future

In late summer 2020, the start-up, which Prof. Weiss founded in 2015 with Dr Julia Rothman, received FDA clearance to commercially distribute Infinix. Reporting on this achievement, local online newspaper the Times of Israel concluded that the clearance “gives Nobio access to the [US] $1.4 billion dental materials market”.

In his interview with DTI, Prof. Weiss said that the COVID-19 pandemic had changed the original roll-out plans for the products. Infinix was to have been made available at the end of 2020 in Israel and the US, but that was changed to spring 2021. In the meantime, free prod-uct samples have been distributed to many practicing key opinion leaders around the world, and according to Prof. Weiss, the feedback has been very positive so far. 

The in situ denture models show the enamel and composite slabs which were used in the University of California, San Francisco clinical trial.

Perhaps, it is rather paradoxical to ask Prof. Weiss where he thinks the future of dental materials is heading, since it seems that he and his team have just set a new gold standard, but for him, the vision is very clear: “We want every possible material to be equipped with Nobio technology so that patients can benefit from this new generation of mate-rials that can shift the balance towards remineralisation and health.” Indeed, Prof. Weiss confirmed that the company is already working on core build-up materials used in root canal therapy. Orthodontic cements and PMMA-based resins for partial and complete dentures are next on the agenda.

Előző cikk

Felmérés szerint a brit fogorvostanhallgatók 40%-a fontolgatja a lemorzsolódást

Következő cikk

Lebenyképzés nélküli implantáció és azonnali ideiglenes korona készítése vékony állcsontgerinc esetén Megagen R2 GATE segítségével

TOVÁBBI CIKKEK

Using digital software for effective root canal therapy

Using digital software for effective root canal therapy

2023-03-31
0

Introduction Root canal anatomy is often complex. Traditional 2D radiographs can give us an idea about the anatomy and its...

Rehabilitation of a failing central incisor

Rehabilitation of a failing central incisor

2023-03-24
0

Introduction Rehabilitation in the anterior zone with implant-supported restorations is a daunting task. Implant-supported rehabilitation in the anterior maxilla requires...

Single-tooth replacement with ceramic implants

Single-tooth replacement with ceramic implants

2023-03-17
0

Introduction Dental implants have helped to improve quality of life for our patients. The material of choice for implants remains...

How clean do sterile implants have to be?

How clean do sterile implants have to be?

2023-03-10
0

The initial phase of the biological response to a placed implant is primarily determined by the implant’s surface characteristics. The...

A multidisciplinary digital  approach to a complex case

A multidisciplinary digital approach to a complex case

2023-03-03
0

Introduction Thanks to digital technology, a growing number of edentulous or partially edentulous patients with residual malocclusion and dysfunction can...

Supporting the osseointegration of ceramic implants

Supporting the osseointegration of ceramic implants

2023-02-24
0

In traditional oral surgery and implantology, the focus is on implant healing and on the local prerequisites for maintaining or...

Továbbiak betöltése
Következő cikk
Lebenyképzés nélküli  implantáció és azonnali  ideiglenes korona készítése vékony állcsontgerinc esetén Megagen R2 GATE segítségével

Lebenyképzés nélküli implantáció és azonnali ideiglenes korona készítése vékony állcsontgerinc esetén Megagen R2 GATE segítségével

Új tanulmány vizsgálja a különböző rákellenes terápiák hatását a szájüregi egészségre

Új tanulmány vizsgálja a különböző rákellenes terápiák hatását a szájüregi egészségre

Endodontikus eredetű arcüreggyulladás nem sebészi kezelése

Endodontikus eredetű arcüreggyulladás nem sebészi kezelése

PRÉMIUM TARTALMAKHOZ

OLVASTA MÁR?

Using digital software for effective root canal therapy

Using digital software for effective root canal therapy

2023-03-31
A fogászati szektor költségcsökkentő intézkedésekkel zárja a bizonytalanságok évét

A fogászati szektor költségcsökkentő intézkedésekkel zárja a bizonytalanságok évét

2023-03-30
Trendek a fogászati technológiában – az analóg és a digitális kéz a kézben járnak

Trendek a fogászati technológiában – az analóg és a digitális kéz a kézben járnak

2023-03-28
Implantátum megtámasztású fogsor újrakészítése

Implantátum megtámasztású fogsor újrakészítése

2023-03-27
Rehabilitation of a failing central incisor

Rehabilitation of a failing central incisor

2023-03-24
Az IDS visszatért: 120.000 látogató vett részt a világ vezető fogászati kiállításának 100. évfordulóján

Az IDS visszatért: 120.000 látogató vett részt a világ vezető fogászati kiállításának 100. évfordulóján

2023-03-23

Upgrade Congress

Dental World

APRÓ

  • Asszisztensi állás
    Dabasi,NEAK finanszírozott praxisomba keresek szakképzett fogászati asszisztenst főállásban. A jelentkezéseket fényképes önéletrajzzal a kallai.zola@upcmail.hu címre várom. Kállai Zoltán Tel.:+36-30/914-3683

    [Több]

  • Fogászati rendelő kiadó a Széll Kálmán tér mellett
    Exkluzív fogászati rendelő kiadó a Széll Kálmán tér mellett hétfő, szerda, pénteki napokra akár műszakonként is. Jelentkezni lehet a kontaimre@gmail.com…

    [Több]

WEBSHOP AJÁNLÓ

  • Fogtechnika éves előfizetés 10 000 Ft
  • Dental Magazinok éves előfizetés 41 000 Ft 23 500 Ft
  • Gengigel Prof 34 990 Ft

VÁLOGASSON!

  • Akciós termékek (14)
  • Fogkefék, Fogkrémek (16)
    • Emmi-Dent fogkefe, fogkrém (9)
    • Ionickiss fogkefék (3)
    • Megasonex fogkefe (2)
    • Philips elektromos fogkefék (2)
  • Gengigel (6)
  • Könyvek, Újságok (38)
    • Szakkönyvek (30)
    • Szaklapok (3)
    • Újság előfizetések (5)
  • Naptár (1)
  • Pólók humoros felirattal (4)

Impresszum

Kiadja: DP Hungary Kft.
1012 Budapest, Kuny Domokos utca 9.
Telefon: +36 30 472 0030, 06-1-793-1874
E-mail: info@dental.hu,
Cégjegyzék szám: 01 09 679976

Felelős kiadó: Nagy Erika
Szerkesztőségi titkár: Bárdos Veronika
Tördelő szerkesztő: Sárközi András
Szakmai tartalom felelős: Dr. Riba Magdolna

IMPRESSZUM

Kiadja: DP Hungary Kft.
1012 Budapest, Kuny Domokos utca 9.
Telefon: +36 30 472 0030, 06-1-793-1874
E-mail: info@dental.hu,
Cégjegyzék szám: 01 09 679976

Felelős kiadó: Nagy Erika
Szerkesztőségi titkár: Bárdos Veronika
Tördelő szerkesztő: Sárközi András
Szakmai tartalom felelős: Dr. Riba Magdolna

Olvasta már?

  • Using digital software for effective root canal therapy
  • A fogászati szektor költségcsökkentő intézkedésekkel zárja a bizonytalanságok évét
  • Trendek a fogászati technológiában – az analóg és a digitális kéz a kézben járnak
  • Implantátum megtámasztású fogsor újrakészítése
  • Rehabilitation of a failing central incisor

KÖZLEMÉNYEK

ÁSZF | Adatvédelem

Dental.hu © 2022

Nincs találat
Összes találat
  • Kapcsolat
  • Webshop
  • Apróhirdetések
  • UPGRADE CONGRESS 2023
  • DENTAL WORLD 2023
  • Cikkek
    • Általános fogászat
    • Digitális fogászat
    • Endodontia
    • Esztétika
    • Fogtechnika
    • Implantológia
    • Lézer technológia
    • Orthodontia
    • Parodontológia
    • Praxismenedzsment
    • Protetika
    • Szájhigiénia
    • Szakmai Hírek
    • COVID-19

Dental.hu © 2022

  • Belépés
Elfelejtett jelszó?
Lost your password? Please enter your username or email address. You will receive a link to create a new password via email.